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Information × Registration Number 0213U006843, 0112U003292 , R & D reports Title Identification and characterization of eukaryotic adaptor proteins which interact with transcriptional and chromatin remodeling complexes popup.stage_title Head Ryndych Alla Volodymyrivna, Доктор біологічних наук Registration Date 10-01-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 As a result of the project revealed that the endocytic adapter protein intersectin , which is predominantly localized in the plasma membrane can be transported into the nucleus. This process is regulated by covalent attachment of ubiquitin molecules to intersectin , which is mediated by the ubiquitin - ligase AIP4. At the core of intersectin binds heterogeneous nuclear ribonucleoprotein K. For the first time it has been shown association of endocytic protein intersectin with Fyn transcripts. Furthermore, overexpression of intersectin resulted in increased expression of c - Myc, p53. These results indicate that the endocytic proteins may regulate gene transcription, and be associated with transport of gene transcripts. Product Description popup.authors Базан Тамара Адамівна Герасимчук Дмитро Олександрович Грязнова Тетяна Анатоліївна Дергай Микола Васильович Кропивко Сергій Вікторович Мордерер Дмитро Євгенович Скрипкіна Інесса Яківна Фоєнко Інна Миколаївна Чаїн Людмила Олександрівна popup.nrat_date 2020-04-02 Close