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Information × Registration Number 0213U006844, 0110U006120 , R & D reports Title Development for technology target-specific search of aminoacyl-tRNA synthetases inhibitors with selective action against specific human infections. popup.stage_title Head Tukalo Mykhaylo, Доктор біологічних наук Registration Date 10-01-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The complexes of synthetical inhibitors with leucyl-tRNA synthetase (LeuRS) Mycobacterium tuberculosis and prolyl-tRNA synthetase (ProRS) Enterococcus faecalis were investigated. Based on the binding modes of three the most active compounds, obtained with molecular docking, we have built pharmacophore model which can be used for further search of inhibitors LeuRS M. tuberculosis. 72 analogs of the most perspective inhibitor of LeuRS M. tuberculosis were selected and tested. It was found two inhibitors with better activity against LeuRS M. tuberculosis. The method for crystallization of LeuRS and ProRS with synthetical inhibitors was proposed.5481 Product Description popup.authors Бджола Володимир Григорович Бояршин Костянтин Сергійович Волинець Галина Петрівна Гудзера Ольга Йосипівна Дудченко Тарас Миколайович Кpикливий Iван Андрійович Коваленко Оксана Петрівна Яpемчук Ганна Дмитрівна Ярмолюк Сергій Миколайович popup.nrat_date 2020-04-02 Close