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Registration Number

0213U007127, 0110U001184 , R & D reports

Title

Comparison analysis of thyroid cancer incidence and characteristic of carcinomas removed in persons of different age groups, who were born before and after the Chоrnobyl accident

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Head

Bogdanova Tetiana; Tereschenko Valeriy,

Registration Date

05-04-2013

Organization

State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine"

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Object: thyroid cancer (TC) incidence, morphological descriptions of TC. Aim: to conduct the analysis of the TC incidence and define the possible structural peculiarities of papillary thyroid carcinomas (PTCs) in the age-matched groups, born before and after the Chernobyl accident. Methods: statistical, morphological, immunohistochemical. Theoretical and practical results: thyroid cancer incidence in Ukraine among children and adolescents at the time of еру accident demonstrated a growing trend during a period from 2009 to 2011. Such trend is conditioned in a greater measure by less contaminated regions, and can testify to gradual reduction to influence of radiation factor. A pathological analysis showed considerable advantage of the PTCs (94,6 %). Histological descriptions the PTCs coincided with certain in a previous period of observation. Significantly increased only the percent of micro-PTCs sized to 1 cm. Univariant and multivariant analyses of radiogenic and sporadic PTCs showed that radiogenic PTCs in children aged up to 4 years at the time of accident and lived in the most contaminated regions of Ukraine, substantially differed from sporadic PTCs in children age-matched group, but born after the accident. Such differences in radiogenic PTCs in children and absence of them in radiogenic PTCs of adolescents and adults can be related to more short latency of development of childhood radiogenic PTCs and higher thyroid radiation doses. The results revealed are basis for the further monitoring of the TC incidence, and comparison of radiogenic and sporadic TC. Efficiency and realization: improvement of diagnostics to TC. Advantage above analogues: comparative multivariant analysis of post-Chernobyl radiogenic and sporadic PTCS in age-matched groups not conducted. Industry of the use: endocrinology, radiation medicine.

Product Description

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Богданова Тетяна Іванівна
Бурко Світлана Валентинівна
Воскобойник Лариса Григорівна
Гулій Тамара Володимирівна
Гулак Людмила Олегівна
Дегтярьова Тетяна Леонідівна
Зурнаджи Людмила Юліївна
Мазурик Наталія Яківна
Однолько Тетяна Анатолієвна
Папій Лука Миколайович
Плиска Надія Петрівна
Сологуб Валерія Борисівна
Терещенко Валерий Платонович
Шпак Виктор Михайлович

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2020-04-02