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Information × Registration Number 0213U007128, 0110U001190 , R & D reports Title Investigation of the etiology and pathogenesis and clinical peculiarities of the physical and sexual development in children and adolescents with somatotropin and gonadotropin related endocrinopathies, improvement the methods of diagnostics and treatment of the disturbances revealed popup.stage_title Head Вolshova Elena, Registration Date 05-04-2013 Organization State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine" popup.description2 The object of study is the disturbences of physical and sexual development in endocrinopathy involving changes in growth hormone and gonadotropin content. Objective: To study the characteristics of the secretion of growth hormone (GH) insulin like growth factor-1 (IGF-1) and protein, it binds in children and adolescents with endocrine disorders associated with changes of GH levels and pituitary gonadotropins, improve the efficiency of diagnosis and treatment of such patients. Methods: Assessment of physical development, the expected final height, x-age for atlas Greulich and Pyle, puberty by Tanner. Determination of GH, IGF-1, IGF-BP-3, gonadotropins, estradiol, testosterone blood radioimmunoassay and immunofermental methods. The content of zinc in hair was determined by X-ray fluorescence spectrometry . Results processed using Microsoft Excel using tailed Student's t-test and the definition of probability index difference "P". The features etiopathogenesis and clinical course of idiopathic growth retardation, syndrome biologically inactive growth hormone. The first time the development and implementation of the method of differential diagnosis (test for sensitivity to treatment with GH definition before and after IGF-1 levels in the blood) syndrome biologically inactive growth hormone (type Kovarsky) and receptor insensitivity to growth hormone (Larona syndrome). A study effectivof the treatment of these patients. In children and adolescents with isolated and multiple pituitary hormone deficiency continued study of the cardiovascular system and lipid metabolism. Identified relative hypercholesteremia, reduction of high density lipoproteins and metabolic violation of the myocardium in patients not treated with immunosuppressive therapy. The changes of the hypothalamic-pituitary-thyroid and - adrenal system in patients with isolated and multiple pituitary hormone deficiency after prolonged treatment by rGH medicin. Found an appearance in these patients hypothyroidism primary or secondary origin on the background of therapy with rGH. After 3-6 months. from treatment with rGH in some patients detected low levels of cortisol in the morning in plasma without clinical manifestations of adrenal insufficiency. The complex technology forecasting rGH effectiveness of therapy in children prepubertal children with growth failure. The data on the dependence of the increase in the content of the form of leptin obesity. In patients with visceral-abdominal form of obesity leptin content was significantly higher than in patients with hlyuteofemoralnoyu form. Product Description popup.authors Большова О.В. Вишневська Ольга Анатолівна Дерев'янко Ганна Анатолівна Кульчицька Наталя Олегівна Лукашук Ірина Вікторівна Маліновська Тетяна Миколаївна Музь Валентина Артемівна Самсон Оксана Ярославівна Спринчук Наталія Андріївна popup.nrat_date 2020-04-02 Close