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Registration Number

0213U007246, 0111U006259 , R & D reports

Title

New heterocyclic compounds - effective sources of biologically-active substances, fluorescent probes, modifiers of supramolecular objects

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Head

Volovenko Yu. M.,

Registration Date

29-04-2013

Organization

National Taras Shevchenko University of Kiev

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Report : 98 p., 85 рiсt., 6 tаbl., 1 addition, 30 references. Research object: nitrogen-, oxygen- and sulfurcomprising geterosystems. Work aim: The development and improvement of preparative methodes and methodics of synthesis of novel geterocyclic compounds for making of novel bioregulators of widespread-spectrum of range, novel photosensitive and fluorescent materials. Research methodes: Methodes of synthesis of model organic substances, geterocyclic substances; NМR-, IR-, UV-, fluorescent spectroscopy; mass- and chromatomass-spectroscopy; methodes of synthesis under high pressure and inert atmosphere; XR- and elemental analysis. The methodes of synthesis of novel isotiochroman-4-оn 2,2-dioxide derivatives and was studied their reaction with nucleophiles and electrophiles. Was conducted the modification of isocoumarine flavonoids. Was studied the reaction of reduction of 3-(carboxyaryl)isocoumarines with potassium borohydride. Was synthesised a number of new derivatives of dihydroisocoumarine and 2-benzopyran-1-one and studiedtheir reactions with secondary amines. Was studied the reaction of 2-(2-(4-hydroxy-(methoxy)phenyl)-2-oxoethyl)benzoic acides with DMFDMA. Was conducted the quantum calculation of obtained structures and was determined an energy-efficient conformere. Was studied the reactions of 7-hydroxyneoflavonee derivatives with malonodinitrile in the presence of ammonium acetate. Was studied the reaction of 4Н-chromen-4-ones with secondary cyclic amines. was elaborated the methode of synthesis of 7'-hydroxy-3,4'-bicoumarines. Was accomplished the systematic investigation of the reaction of 3-aryl/аryoxy/hetarylchromones with hydrazine-hydrateand it derivatives. Was studied the reactions of 1-ethoxyisoindole with active dienophiles. Was synthesised a number of new Mikhaele mono- and bis-adductes.Was studied the Biginelli reaction in presence of Me3SiCl for various trifluoromethyl-1,3-diones. Was opened a new multicomponente reaction of Biginelli type.

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Єгорова Т.В.
Бійцева А.В.
Бойко О.М.
Войтенко З.В.
Воловенко Ю.М.
Воловненко Т.А.
Горбуленко Н.В.
Кисіль А.І.
Коваленко Н.В.
Москвіна В.С.
Пласконь А.С.
Попов К.С.
Потіха Л.М.
Ткачук Т.М.
Туров О.В.
Цапко М.Д.
Чекотило О.О.
Шилін С.В.
Шишкіна О.О.
Шокол Т.В.

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2020-04-02