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Information × Registration Number 0213U008210, 0111U003249 , R & D reports Title To develop of short course of antituberculosis chemotherapy for patients with co-infection tuberculosis/HIV popup.stage_title Head Feshchenko Yuriy Ivanovich, Registration Date 26-12-2013 Organization SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine" popup.description2 Object: patients with co-infection tuberculosis/HIV. Aim: increase the effectiveness of chemotherapy. Methods: clinical, radiological, laboratory, microbiological. Was stadied the structure of patients with co-infection TB/HIV: almost all of patients was shownwidespread tuberculosis process, in 60,0 % - a destructive process and sputum positive and in 61,9 % - advanced immunodeficiency. The primary drug resistance was 23,3 %, including MDR - 6,8 %. Was stadied the results of standard chemotherapy regimens patients co-infected TB/HIV, was found that they were not enough effctiveness for treatment, has been cured 51,7 % of patients. Was stadied the effect of anti-tuberculosis therapy on the immune status, was found that during the main course, a decrease in the number of CD4 + lymphocytes in 87,7 % of patient with advanced and in 81,3 % of patients with moderate immunodeficiency. Antituberculosis chemotherapy leads to temporary improvement of immunity in 61,5 % of patients, which dead 9,6 % of patients. When prescribing ART to patients with severe immunodeficiency survival rate is 4 times higher. ART does not significantly increase the number of adverse events (13,6 %), but significantly increases the effectiveness of treatment as sputum negative in 1,8 times. Was designed short regimen of antituberculosis chemotherapy with including moxifloxacin, which allows to increase by 37,5 % effectiveness antituberculosis chemotherapy wiht comparing of standard modes and assign ART more patients with advanced immunedeficiency at the end of the intensive phase of chemotherapy (93,3 % vs. 63,3 %) and 2 times to reduce the frequency and severity of the syndrome by restoring immune system function due to more effective treatment of tuberculosis. Recurrences of tuberculosis was observed in 21,4 % of HIV-infected patients after treatment of tuberculosis. In the absence of ART early recurrences occur within the time frame (24,4 ± 2,4) months, late - (57,7 ± 3,3) months. Appointment of ART significantly reduces the number of relapses in these patients to 14,8 %. Sphere of application - phthisiology Product Description popup.authors Манів Л. Я. Марченко Н. А. Погребна М. В. Роєнко Г. М. Сенько Ю.О. Фещенко Юрій Іванович Черенько Світлана Олександрівна popup.nrat_date 2020-04-02 Close