Registration Number
0213U008230,
0111U002205
, R & D reports
Title
To analyse the influence of cell-progenitors of different nature on immune and neurodistrofic processses in the experiment
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Head
Lisyaniy Nicolay,
Registration Date
26-12-2013
Organization
State institution ''Institute of Neurosurgery n.acad. AP. Romodanov NAMS of Ukraine''
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The predecessors of mesenchymal stem cells are the progenitor cells which may be isolated from adipose tissue and marrow of the rats and mice by method of adhesion to plastic have been establisthed by conducted study. The adhesive cells which have been isolated from marrow and adipose tissue by long duration cultivation until 25-30 days have been transformed into similar fibroblastic mesenchymal stem cells which have different biological properties and can be transformed into neurogenic stem cells. Progenitor cells and MSC were found to have immunosuppressor properties in vitro and in vivo and to inhibit the development of the reaction of owher against transplantat and development of the experimental autoimmune encephalomyelitis. The study of antitumor activity of MSC has shown they are able to inhibit the growth of brain glioma 101.8 of rats upon the definite conditions. MSC and their precessors have an influence on regenerative processes namely they are able to accelerate and inhibit the regeneration skin and resume the function of the ischemic nerve during the experiment MSC and their predecessors secrete the humoral factors during the cultivation which have similar properties pointing out of the perspectivity of the further research of these specific factors. Received results indicate the importance and availability of study.
Product Description
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Єгорова Діана Михайлівна
Бєльська Людмила Миколаївна
Васлович Вікторія Викторовна
Гнєдкова Ірина Олександрівна
Задорожна Олена Вікторівна
Золотоверх Олександр Михайлович
Ключнікова Антоніна Іванівна
Лісяний Микола Іванович
Потапова Антоніна Гнатівна
Семенова Віра Михайлівна
Стайно Лариса Петрівна
Станецька Діана Миколаївна
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2020-04-02
