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Registration Number

0214U001066, 0111U002039 , R & D reports

Title

Patterns of individual variations of cytogenetic effects in cancer patients during therapeutic external gamma-irradiation.

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Head

Vinnikov V.A.,

Registration Date

17-01-2014

Organization

Grigor'ev Institut for Medical Radiology

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Research object - The individual variability of cytogenetic effects in blood lymphocytes and adverse radiation effects in 30 mammary cancer patients and 70 gynecological cancer patients. Research aim - To reveal the patterns of formation of borderline changes of chromosome aberration yield in cancer patients' blood lymphocytes during therapeutic external gamma-irradiation and to evaluate the prognostic potential of cytogenetic damage as clinically meaningful markers at radiotherapy. Methods and equipment - conventional cytogenetic analysis of human peripheral blood lymphocyte culture, statistical, microscopes Biolam I, Axioskop, Micros MC 300X. Theoretical and practical results. The patterns of cytogenetic damage yield changes were determined and the parameters of their inter-individual variability were quantified in blood lymphocytes of patients with mammary cancer, uterine and ovarian cancer depending on the therapeutic irradiation scheme. The information-biophysical model was developed in order to describe the dynamics of chromosome aberration frequency in human blood lymphocytes during fractionated localized irradiation. A new method of prognostic assessment of adverse radiation effects in skin was developed, which was based on the combination of catamnesis and cytogenetic data in patients during radiation treatment. Novelty - For the first time the magnitude of the inter-individual variability of the chromosome aberration yield dynamics was quantified and the peculiarities of cytogenetic effect incidence in vivo during radiotherapy were determined depending on the tumor localization and treatment scheme. For the first time the methodology of constructing of the applied prognostic systems based on clinically-meaningful cytogenetic markers during radiotherapy was suggested. Area of potential usage - medicine, medical radiology, radiobiology, radiotherapy, oncological institutions.

Product Description

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Артамонова Н.О.
Безугла В.С.
Вінніков В.А.
Гаряча В.
Кондрашова О.І.
Мазник Н.О.
Пшенічна Н.Д.
Свинаренко А.В.
Сипко Т.С.

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2020-04-02