Registration Number
0214U002542,
0111U001065
, R & D reports
Title
Explore the mechanisms of development of fibrotic processes in chronic pancreatitis and improve technologies for their surgical correction.
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Head
Shevchenko Borys F.,
Registration Date
15-01-2014
Organization
SI "Institute of Gastroenterology NAMS of Ukraine"
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Report on NIR: 304 with., 99 lines., 62 tables., 7 additions, 100 sources. It is probed - 125 patients with complicated chronic pancreatitis, 142 experimental animals. Research purpose: improvement of results of surgical treatment of patients complicated chronic pancreatitis on the basis of study of processes of inflammation, fibrosis and regeneration of pancreas parenchyma and ground of expedience of application of new technologies of their surgical correction. Research methods - clinical, experimental, biochemical, instrumental, morphological, immunological, microbiological and statistical. An apparatus is vehicles of ultrasonic research, computer tomography, oesophagogastrodyodenoscope, roentgensurgery setting, light microscope, photoelectrocolorymeter, spectrophotometer. It is set that weight of complications of chronic pancreatitis depends on the term of disease and degree of fibrotic alteration of pancreas which at chronic pancreatitis takes a place from destruction or atrophy of ferrous fabric depending on etiologic factors. Biochemical, immunological indexes and features of instrumental researches which allow to set activity of inflammation and degree of fibrotic transformation of pancreas at complicated chronic pancreatitis are certain. It is proved that at the choice of method of treatment of complicated chronic pancreatitis it is necessary to pay a regard to activity of inflammation and degree of fibrotic of pancreas. At the surgical correction of complications of chronic pancreatitis on a background active inflammation conservative therapy and implementation of minimalinvasion palliative surgical interferences is shown final correctings surgical interferences must be executed on a background nonactive inflammation and taking into account the degree of fibrotic of pancreas. The algorithm of diagnostic and medical tactic, which allows to set character of complications of chronic pancreatitis, set a kind and term of treatment and concretely necessary operation taking into account activity of inflammation and degree of fibrotic of pancreas, is developed, that enables to reduce the number of postoperative complications and improve quality of life of patients. Introduction: 5 patents, 3 requests on a patent, 18 lectures, 23 articles, 24 theses, 1 methodical recommendations, 1 informative list. PANCREAS, FIBROSIS, COMPLICATIONS, DIAGNOSTICS, SURGICAL TREATMENT, EXPERIMENTAL PANCREATITIS.
Product Description
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Аржанова Г.Ю.
Бабій О.М.
Гайдар Ю.А.
Галінський О.О.
Галенко О.П.
Гравіровська Н.Г.
Крилова О.О.
Макарчук В.А.
Орловський Д.В.
Ошмянська Н.Ю.
Пролом Н.В.
Ратчик В.М.
Руденко А.І.
Татарчук О.М.
Тропко Л.В.
Фотіна М.О.
Шевченко Б.Ф.
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2020-04-02
