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Information × Registration Number 0214U003271, 0111U005205 , R & D reports Title Influence of Acume Myocardial Infarction, Arterial Hypertension and Diabetes Mellitus 2 type on Myocardial Ultrastructure Remodelling and Heart Failure Development popup.stage_title Head Kyyak Yulian Hryhorowich, Доктор медичних наук Registration Date 28-01-2014 Organization Danylo Halytsky Lviv National Medical University popup.description2 The investigation reveals cellular mechanisms of heart failure (HF) development in the cases of arterial hypertension (AH), diabetes mellitus (DM) and ischemic heart disease (IHD). Ultrastructural examination of myocardial express-necropsies of 38 patients who died from acute myocardial infarction (AMI) and 32 myocardial biopsies obtained during coronary artery bypass surgery or ventriculoplasty of chronic aneurism wall was performed. It was revealed that AH causes microvascular remodeling and narrowing as well as cardiomyocyte (CMC) hypertrophy and hibernation, leading to heart failure development. DM causes diabetic microangiopathy and cardiomyopathy in the result of microvessel reduction and CMC hibernation and dysfunction. The development of AMI in the patients suffering from AH and DM stimulates CMC necrosis and apoptosis in intact and near necrotic zones of the left ventricle, causing HF progression. Myocardial revascularization and prescription of cardioprotective drugs with antiapoptotic effect in AMI cases and comorbidity may prevent the severity of the heart failure and systolic dysfunction of the left ventricle in AH and DM patients. Product Description popup.authors Барнетт Ольга Юліанівна Беш Дмитро Ігорович Капустинський Олег Олегович Ковалишин Василь Іванович popup.nrat_date 2020-04-02 Close