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Information × Registration Number 0214U003700, 0110U006192 , R & D reports Title The development of new approaches to combinational cancer enzymotherapy based on amino acids starvation popup.stage_title Head Stasyk O.V., Кандидат біологічних наук Registration Date 17-02-2014 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 At the fourth stage of the work the role of proteasome protein degradation in response of tumor cells to starvation for certain amino acids and related signaling pathways was investigated. It was established that proteasome inhibitors - MG132 or bortezomib under arginine starvation decreased cell viability of human lung carcinoma A549, but pronounced additive effect was not observed. A549 cells after the combined influence of proteasome inhibitors MG132 or bortezomib and inhibitor of authophagy - chloroquine - had a reduced ability to restore growth compared to cells exposed to a single factor. However, the effect of the combination of these inhibitors and starvation for arginine on cell viability is moderate. Expression of arginyltransferase which regulates the process of proteasome degradation of the some regulatory proteins, is regulated at the translational level during starvation for arginine . Starvation for arginine selectively damages the proteasome degradation of the regulatory protein RGS4, depending on its N-terminal arginylation. Product Description popup.authors Барська М.Л. Бобак Я.П. Вовк О.І. Маєвська О.М. Шуваєва Г.Ю. popup.nrat_date 2020-04-02 Close