Registration Number
0214U003756,
0111U000511
, R & D reports
Title
- To investigate the disorders in the state of oral tissues at system endotoxinemia and to elaborate the methods of their correction.
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Head
Levitskij Anatolij Pavlovich,
Registration Date
24-02-2014
Organization
State Establishment "The INSTITUTE of STOMATOLOGY NATIONAL ACADEMY of MEDICAL SCIENCES of UKRAINE"
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The subject of investigation: rats of Vistar line, the preparations of lipopolysaccharide from E. сoli 0111:В4 and Salmonella typhi, oral tissues, enzymes, mucosa-adhesive gels, the preparations of bioflavonoids. The aim of investigation is to study the pathological influence of lipopolysaccharide upon tissues of oral cavity and other organs, the elaboration of therapeutic and preventive preparation in the form of mucosa-adhesive gels with bioflavonoids. The methods of investigation are experimental, biochemical and statistic. The equipment: spectrophotometer UV mini-1240 Shimadzu, photoelectrocolorimeter KFK-3, ionometer рН-150М, balance laboratory electronic analytical ESJ-60, centrifugal machine PC-6. The scientific novelty: the role of system endotoxinemy in pathogenesis of stomatological diseases was determined for the first time: the intramuscular introduction of lipopolysaccharide results in the development of inflammation, dysbiosis, intensification of lipids peroxide oxidation, decrease in the activity of antioxidant protection in oral tissues. The pathogenous influence of lipopolysaccharide at its application on oral tissues upon the state of vitals of experimental animals was revealed: the development of inflammatory and dysbiotic phenomena, intensification of lipids peroxide oxidation simultaneous to the reduction of the activity of antioxidant protection and nonspecific immunity in liver, kidneys, urinary bladder and retina of rats. The therapeutic and preventive effectiveness of the preparations of bioflavonoids "Quertulin", "Extravin" and bilberry paste under the influence of lipopolysaccharide was displayed. The effective form of the use of bioactive substances in dentistry, i.e. mucosa-adhesive gels, is substantiated. The recipes of gels with the introduction of Quertulin, quercethin, vine leaves extract, lysozyme, phytolysozyme, prebiotics from soy, prebiotic Symbiter, were elaborated. The practical value. The technology of the production was worked out; the license by the head sanitary inspector of the MH of Ukraine for the application of the food additive "Quertulin", phytogels with quercethin, Quertulin, vine leaves extract, phytolysozyme, Symbiter, "Galsodent" was obtained. The materials of SRD are published in 50 articles, 26 theses. 5 monographs, 4 practical policies are issued, 7 patents are obtained. ORAL TISSUES, DYSBIOSIS, INFLAMMATION, LIPOPOLYSACCHARIDE, PHYTOGELS, BIOFLAVONOIDS, QUERTULIN, PHYTOLYSOZYME.
Product Description
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Аншукова Ольга Ігорівна
Варжапетян Сурен Діасович
Гончарук Сергій Володимирович
Давиденко Ігор Анатолійович
Декіна Світлана Сергіївна
Дем,яненко Світлана Олександрівна
Кнава Ольга Едуардівна
Кушнир Євген Миколайович
Левченко Олена Михайлівна
Макаренко Ольга Анатоліївна
Михайленко Ірина Олександрівна
Почтар Вікторія Миколаївна
Пустовойт Петро Іванович
Романова Юлія Георгіївна
Романовська Ірина Ігорівна
Селіванська Ірина Олександрівна
Скидан Карина Володимирівна
Скидан Максим Ігорович
Ступак Олена Павлівна
Фурдичко Анастасія Іванівна
Хлистун Наталія Леонідівна
Ходаков Ігор Володимирович
Хромагіна Лариса Миколаївна
Цісельська Ольга Юріївна
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2020-04-02
