Search academic texts

Information × Registration Number 0214U003836, 0113U003187 , R & D reports Title Development of the theoretical basis for the synthesis of new nitrogen- and sulfur-containing compounds - potential drug substances with various biological actions. popup.stage_title Head V. Novikov, Registration Date 03-03-2014 Organization Lviv Polytechnic National University popup.description2 Methods for the synthesis of previously unknown thiosulfonate, sulfide, sulfonyl and heterocyclic derivatives, new hydrazones with the shielded phenol moiety were developed and the possibilities of their practical application were investigated. By selectively putting pharmacophore fragments as substituents in the heterocycle nucleus convenient preparative methods for obtaining new compounds were developed and their physicochemical properties were investigated. A convenient preparative methods for the synthesis of sulfonic acids, sulfonyl chlorides based on substituted 1,4-naphthoquinone were developed and the possibility of their use as synthons for obtaining new sulfonates, sulfonamides, sulfur- and of nitrogen-containing heterocyclic compounds was proved. A new method for the synthesis of azomethines with spatially shielded phenol via condensing the keto derivatives of 2,6-di-tert-butylphenol with the appropriate hydrazine was developed and the stable radical, in which phenoxyl-hydrazylic mesomerism, was synthesized. It was shown that one of the defining conditions of the existence of the stable radical is the presence of two or more absorption maxima in the visible region in its electronic spectrum, i.e. effective intramolecular coupling is implemented, as confirmed by the example of the synthesized 2,6-di-tert-butyl-4-(diphenyl-hydrazonomethyl)-phenyl radical. A synthetic strategy using halogen-containing quinoxalines for the synthesis of heterocyclic nitrogen-containing s-thiosulfoacid esters by nucleophilic substitution of halogen atoms in thiosulfonate fragment was developed and the main directions of the reaction course depending on the conditions of reaction conduction and the structure of thiosulfonates were determined. The interaction was studied and conditions of the reaction of binucleophile thiosulfoacid salts of 2,3-dyhloroquinoxaline were determined for the first time. The composition and structure of the synthesized compounds was confirmed by elemental analysis and IR, UV spectroscopy, electronic magnetic and magnetic proton magnetic resonance. The physicochemical properties of the synthesized naphthoquinone derivatives, quinoxaline, hydrazones with spatially shielded phenol were studied. A computer-predicted biological screening using PASS software for the synthesized compounds and among then the compounds with the highest number of different types of activity (bactericidal, fungicidal, anticancer, etc.) were selected. For some of them experimental biological research was conducted.5481 Product Description popup.authors Болібрух Х.Б. Карпенко О.Я. Кархут А.І. Ковальчук О.І. Крвавич А.С. Лубенець В.І. Монька Н.Я. Новіков В.П. Фігурка О.М. Хом'як С.В. Хоміцька Г.М. Шиян Г.Б. Яремкевич О.С. popup.nrat_date 2020-04-02 Close