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Information × Registration Number 0214U005076, 0111U000174 , R & D reports Title The elaboration of diagnostic algorythms and treatment of non-alcogolic fatty liver disease in patients with II type diabetes mellitus, which are pathogenically supported popup.stage_title Head Kravtchun Nonna Alexsandrovna, Registration Date 31-01-2014 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 Object of research: non-alcoholic fatty liver disease in patients with diabetes mellitus (DM) type 2. Objective: To improve the diagnosis and treatment algorithms non-alcoholic fatty liver disease in patients with type 2 diabetes and find additional mechanisms of liver disease in patients DM type 2 , depending on the presence or absence of concomitant autoimmune disorders . Methods: clinical , biochemical, immunological, molecular - genetic .The studies found microalbuminuria in 50% of patients with DM type 2 with non-alcoholic fatty liver disease, diabetic encephalopathy was diagnosed in 60.0 % of patients. Changes in emotional state in the form of depression, and cognitive impairment are more common in female patients, in 95.7 % of them showed signs of moderate dementia. 80% of patients with type 2 diabetes and was diagnosed with stage non-alcoholic fatty liver disease steatohepatitis moderate activity , the main manifestations of which, along with clinical signs are the presence of mesenchymal and cytolysis syndrome - an inflammatory syndrome. The average level of IL- 6 in patients exceeded the normal values. Clinically significant violation lipid peroxidation values compared with healthy individuals, contributing to changes of the liver. When non-alcoholic fatty liver disease regardless of body weight observed high levels of non-esterified fatty acids, insulin and low adiponectin levels, confirming their role in the development non-alcoholic fatty liver disease even in individuals with normal body weight. Clinically significant increase of the level of retinol-binding protein - 4, in patients with non-alcoholic fatty liver disease, which proves the usefulness of this indicator for future use as a diagnostic marker non-alcoholic fatty liver disease. Using drugs alpha - lipoic acid complex therapy in treatment of non-alcoholic fatty liver disease improved carbohydrate and lipid metabolism. Preparations of essential phospholipids, thiotriazoline , ademetionine, L - ornithine - L - aspartate improves carbohydrate metabolism and reduce the activity of mesenchymal - inflammatory syndrome in non-alcoholic fatty liver disease. Application area: сlinical endocrinology, family medicine. Product Description popup.authors Алексєєва Ірина Ігорєвна Атраментова Любовь Олексіївна Гладких Олександр Іванович Гончарова Ольга Аркадієвна Горшунська Марьяна Юрьєвна Гринченко Тамара Степанівна Дорош Олена Григорьєвна Завадська Наталья Володимирівна Зайцева Людмила Іванівна Кравчун Нонна Олександрівна Красова Наталья Лещенко Жанна Миколаївна Олійникова Світлана Петрівна Полторак Вікторія Віталієвна Романова Ірина Петрівна Тижненко Тетяна Васильєвна Тяжелова Ольга Володимирівна Холодний Олександр Васильович Черняєва Анна Олександрівна Чернявська Ірина Вікторівна popup.nrat_date 2020-04-02 Close