Registration Number
0214U005124,
0111U001774
, R & D reports
Title
Combined investigation of genetic-based peculiarities of NF-kB-mediated signal transduction, which determines the development of chronic systemic inflammation in patients with the metabolic syndrome and type II diabetes mellitus
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Head
Kaidashev Igor Petrovich,
Registration Date
06-02-2014
Organization
Ukrainian Ministry of the Health Public Service, Ukrainian Medical Stomatological Academia,
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The conception of NF-kB permanent activation (long-term and low intensity activation) has been formulated for the first time as a possible model of the pathological process by insulin resistance, chronic inflammation, hypertension, endothelial dysfunction and dyslipidemia. The content of intracellular NF-kB has been studied among CD40+ cells populations under the influence of pioglitazone in patients with metabolic syndrome and coronary heart disease. The data on blockade of NF-kB activation has been obtained under the action of endogenous proinflammatory cytokines (by the example of CD40+ mononuclear cells of peripheral blood) against the background of metformin inclusion in the complex treatment of patients with metabolic syndrome and coronary heart disease. The reduction of NF-kB expression levels and apoptosis processes of CD64+ cells has been determined in the mononuclear cells suspensions of peripheral blood under the influence of PPAR gamma activator. The distribution of genotypes frequencies and alleles of PPARgamma2 gene has been investigated with due consideration of patient's lipid metabolism changes. The high therapeutic efficacy of metformin has been detected in patients with coronary heart disease against the background of type 2 diabetes mellitus or metabolic syndrome who have the genotype of Pro / Pro PPARgamma2 gene.
Product Description
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Ізмайлова Ольга Віталіївна
Весніна Людмила Едуардівна
Лавренко Анна Володимирівна
Мамонтова Тетяна Василіївна
Микитюк Марина Володимирівна
Пилипенко Ольга Анатоліївна
Скочко Ольга Вікторівна
Тарасенко Костянтин Володимирович
Шевченко Юлія Сергіївна
Шликова Оксана Анатоліївна
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2020-04-02
