Registration Number
0214U005481,
0112U000003
, R & D reports
Title
Improving diphtheria and tetanus surveillance at decrease of immunized population
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Head
Hladka Olena,
Registration Date
19-01-2015
Organization
State Institution "Lviv Research Institute Epidemiology and Hygiene Ministry of Health of Ukraine"
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Purpose of study - to improve epidemiological surveillance system for diphtheria and tetanus by studying the characteristics of the epidemic process of development of modern regulatory guidance documents on epidemiological control of these infections. Object - statistics on morbidity, bacteriocarrier, mortality, lethality; strains of corynebacteria. Methods - epidemiological, serological, bacteriological and statistics. Equipment - pH meter, weight batcher. As a result of monitoring during 2012 - 2014 revealed a high incidence of tetanus (0,05-0,04 per 100 thousand.), Including children (0,06-0,03 per 100 thousand.) on the back of reduced diphtheria epidemic process (0,02-0,01 per 100 thousand.), indicating incomplete registration of cases of diphtheria, poor quality of diagnosis and course of hidden epidemic process. Established trend to a sharp decline in vaccination coverage (in 2014 vaccination of children dropped to 31.2 - 0.5% of adults - 2.8%) and intensity of population immunity (the increase of seronegative and conditional protected against diphtheria and tetanus persons in age of 1-2, 5-6, 13-14, 38-57 years, reducing the number of people with high levels of immunity), which creates an unfavorable prognosis for the development of epidemic process of diphtheria and tetanus. Studied the structure of diphtheria susceptibility to antibiotics of different groups. For the first time discovered a direct correlation between bacteriostatic and bactericidal activity of penicillin on C.diphtheriae, the criteria for assessing susceptibility to penicillin dilution method. Carried out measures to support the strains of corynebacteria collection. The new normative - methodical documents on improving epidemiological surveillance of diphtheria and tetanus (guidelines "Information technology in monitoring of population immunity against diphtheria and tetanus," Draft Order of the Ministry of Health of Ukraine "Measures of prevention and control of diphtheria in Ukraine"). The results of research are introduced in guidelines, draft order, 3 information letters, 2 innovations , 3 information-analytical reviews, 5 articles , 23 theses reports, 14 reports. Areas of application: medical institutions, research institutes, universities.
Product Description
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Геник Ігор Дмитрович
Мотика Олена Ігорівна
Сіренко Іванна Семенівнам
Чумаченко Світлана Семенівна
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2020-04-02
