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Information × Registration Number 0214U005658, 0111U002349 , R & D reports Title To explore chemical and pharmaceutical properties and to create scientific and technical documentation for soluble preparation of 1-(o-chlorophenyl)-1-(p'- chlorophenyl)-2,2-dichloroethane (o,p'-DDD) in adrenal glands in treatment of illness of Itsenko-Cushing and tumors of adrenal cortex. popup.stage_title Head Bal'on Yaroslav Grigorovisch, Registration Date 06-02-2014 Organization State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine" popup.description2 An aim of work is development of normative analytical documentation on injection solution o,p'-DDD, that would answer the requirements of the State pharmacopoeia of Ukraine. A research object is a soluble form 1-(o-chlorophenyl)-1-(p'- chlorophenyl)-2,2-dichloroethane (o,p'-DDD). Methods of researches are traditional methods of analytical, organic and pharmaceutical chemistry with the use of physical and chemical methods of researches (UV- and mass-spectrometry, gas-liquid chromatography, TLC). An equipment is a set of laboratory glass tableware, heater devices, magnetic mixers, spectrophotometers Shimadzu UV - 3100, Varian VXR - 300, gas chromatograph "Хром-5", gas chromato-mass-spectrometry Hewlett Pacard GC/MS 5890/5972. As a result of undertaken studies the optimal terms of receipt are found o,p'-DDD. It is set that in an injection form o,p'-DDD are absent mechanical admixtures and concomitant including. The terms of sterilization are offered it is shown that in these terms preparation does not change, and efficiency of method of sterilization is tested by the method of membrane filtration. It is set that injection form o,p'-DDD belongs to IV class of low-toxic substances. It is set that a border concentration of bacterial endotoxins in preparation is 3,5 units/ml. Shown, that it is not toxic and answers the requirements of SPhU. Use-by of standards of preparation date is 3,9 year. Divisions "are worked out packing", "transporting" that "storage". On the basis of the got results analytical normative documentation that includes 13 indexes is created, that answers the requirements of SPhU. A purview is medicine. Product Description popup.authors Вакуленко Лідія Іванівна Сімуров Олексій Володимирович Точілкіна Лілія Михайлівна popup.nrat_date 2020-04-02 Close