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Information × Registration Number 0214U006213, 0112U003750 , R & D reports Title Design, synthesis and biological testing of new heterocyclic inhibitors of topoisomerase I as potential antitumoral agents popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 19-02-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Several dozens of new compounds of various classes were obtained and studied as potential inhibitors of topoisomerase I. Compounds completely inhibiting enzyme in vitro at micromolar concentrations were found. The mechanism of biological activity of inhibitors was studied. Highly sensitive fluorescent labels for the detection of nucleic acids in gels in picogram quantities were found among cyanines. Compounds with high antitumor activity in U87MG cell culture (glioma) were found: acridine, phenazine and benzimidazole derivatives with IC50 in the range 208 uM and cyanines active at submicromolar concentrations (IC50 0.5-0.7 uM). Product Description popup.authors Ільченко М.М. Дубей Л.В. Костенко О.М. Криворотенко Д.В. Кузів Я.Б. Негруцька В.В. popup.nrat_date 2020-04-02 Close