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Information × Registration Number 0214U006216, 0113U002981 , R & D reports Title Molecular design, synthesis, biological testing and study of the mechanism of action of functionalized iron(II) clathrochelates as inhibitors of some therapeutically important enzymes popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 19-02-2014 Organization Institute of molecular biology & genetics popup.description2 The effect of a series of iron(II) clathrochelates on the activity of HIV-1 virus protease was investigated for the first time in the in vitro test system based on recombinant enzyme and chromogenic peptide substrate. Optimal conditions of enzymatic reaction and quantitative analysis of the activity of compounds was elaborated which was performed by spectrophotometric method. Protease inhibitors active at micromolar concentrations (10-20 uM) were found. Product Description popup.authors Ільченко М.М. Дубей Л.В. Костіна В.Г. Кузів Я.Б. Негруцька В.В. popup.nrat_date 2020-04-02 Close
R & D report
Molecular design, synthesis, biological testing and study of the mechanism of action of functionalized iron(II) clathrochelates as inhibitors of some therapeutically important enzymes
Head: Dubey Igor. Molecular design, synthesis, biological testing and study of the mechanism of action of functionalized iron(II) clathrochelates as inhibitors of some therapeutically important enzymes. (popup.stage: ). Institute of molecular biology & genetics. № 0214U006216
1 documents found

Updated: 2026-03-27


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