Registration Number
0214U006332,
0111U001402
, R & D reports
Title
Optimization of diagnostics and antimicrobial therapy of inflammatory processes of taking into account the communicative properties of microorganisms
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Head
Minukhin V.V.,
Registration Date
05-03-2014
Organization
3.Kharkov national medical university
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The object of study is patients with purulent -septic and gynecological diseases, microorganisms, antibacterial drugs. Objective: To optimize the diagnosis and antimicrobial treatment of inflammatory processes to the communicative properties of microorganisms through the development of new schemes combined use of antimicrobial drugs, essential oils and immunomodulatory drugs. Methods of research - experimental, microbiological, clinical, laboratory and statistical. Found that a combination of fluoroquinolone gatifloxacin with cephalosporins cefotaxime and ceftriaxone have a synergistic effect with respect to the reference strains of S. aureus, E. coli, E. faecalis, and clinical bacterial strains isolated from patients with gynecological inflammatory processes. Definitely, manuka essential oil is highly reactive with gram-positive bacteria and fungi of the genus Candida , and has moderate activity against gram-negative facultative anaerobic bacteria. Manuka oil potentiates the antimicrobial properties of a number of antibiotics, namely azithromycin, cefuroxime, cefoperazone, doxycycline. Found that the ability of clinical isolates in the formation of biofilms is higher than the reference strains, the highest average optical density figures were installed in biofilms are formed by a consortium of C. albicans and S. aureus. In identifying the actions of antimicrobial agents in respect of the consortium C. albicans and S. aureus were quite effective combination of the following: terbinafine and benzoyl peroxide, terbinafine, erythromycin and essential oil of wormwood , terbinafine , erythromycin and laferon . The analysis of the etiological structure of surgical infections suggests that during the years 2000-2010 the main etiological factor of intra-abdominal infection was E. coli, which stood as a monoculture and in association with a predominantly gram-positive organisms. P. aeruginosa was the second most common selection for almost all disease entities. Therefore, when assigning empirical antimicrobial therapy needs attention antibiotic primarily active against this microorganism.
Product Description
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Габишева Людмила Степанівна
Граматюк Світлана Миколаївна
Замазій Тетяна Миколаївна
Коваленко Наталія Іллівна
Конь Катерина Володимирівна
Косілова Ольга Юріївна
Кочнєва Олена Володимирівна
Мішина Марина Митрофанівна
Мозгова Юлія Анатоліївна
Сіріца Ганна Володимирівна
Ткаченко Вікторія Леонідівна
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2020-04-02
