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Information × Registration Number 0214U006741, 0111U001425 , R & D reports Title Mechanisms of recovery of T-cell level of the immune system in acute lymphoblastic leukemia in children. popup.stage_title Head Dubey Leonid Yaroslavovych, Registration Date 12-02-2014 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 In children with acute lymphoblastic leukemia (ALL), significantly affects T-cell immunity due to suppressive influence of leukemic clone and cytotoxic effect of polichemotherapy program were detected. During the treatment protocol observed a significant decrease in its performance, which after completion of cytostatic therapy and for the duration of long-term remission gradually normalized, reaching a level of age norms. Indexes of T-cell immunity, including the absolute number of T lymphocytes and their subsets at different stages of treatment and long-term remission terms are non-linear recovery. The degree of violation of this immunity depends on the age of the patient. A more prolonged and deep depression is the T-lymphocytes in young children. In older children indexes of T-cell population quickly approaching normal levels, gaining the maximum value in the long-term remission. Given immunophenotyping subvariant of ALL in children the basic indexes of T-cell have their dependency changes from it. Good regeneration of basic indexes of cellular immunity were in a "pure" B and "pure" T-ALL. Moreover, during the last immunophenotyping subvariant of disease a regenerative processes are more dynamic. It is important that the presence of myeloid markers on both B-and T-blasts in the dynamics of disease processes stimulate the recovery of immunocompetent cells in the core group of children. This is especially noticeable in the B+T +My-ALL.Regeneration of CD3+CD4+-lymphocytes in the peripheral blood of children of younger group with ALL, is thymus-dependent way, ie mainly by CD4+CD45RA+-cells. Adolescents 11-14 years restoring of CD3+CD4+-lymphocytes is thymus-independent way, ie mainly by CD4+CD45R+-cells. CD3+CD8 +-cells regenerate faster than CD3+CD4+- T cells through their CD3+CD8+CD28-- subpopulation. T-killer/suppressor cells do not require thymus residual activity and completely restored in less than three months after completion of treatment program ALL. Product Description popup.authors Лук'янова Ання Сергіївна Міляшкевич Світлана Павлівна Мазур Лілія Петрівна Матвієв Ірина Богданівна popup.nrat_date 2020-04-02 Close