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Information × Registration Number 0214U006900, 0111U002658 , R & D reports Title Improving of the prediction of AIDS' spread in Ukraine by the establishing of carrier's prevalence of HIV susceptibility and protective genes in populations popup.stage_title Head Akopyan Hayane, Доктор медичних наук Registration Date 05-03-2014 Organization Scientific-research institute of Hereditary pathology popup.description2 The frequency of CCR5del32 mutation of chemokine receptor CCR5 gene among Western Ukraine population has been determined as 17.5 % and is higher than in other regions of Ukraine. The frequency of mutations CCR2-64I of chemokine receptors CCR2 gene among Western Ukraine population is 16 % and is corresponding with that in other European ethnic groups. The obtained results has shown that the frequency of mutation SDF-1 3'A - 33.5 % of Western Ukraine inhabitance is considerably higher than in other ethnic groups. The heterozygous mutation CCR2-64I was detected twice more often among women than in men. It has been identified nineteen compounds heterozygous for different mutations of chemokine receptor genes in the study group. Number of people do not carried any protective genotype is 33 %. A genotyping HLA-DRB1 and HLA-DQA1 loci in healthy individuals from the population of Western Ukraine was performed and distribution and frequency of alleles was established. The distribution of HLA-DRB1 and HLA-DQA1 genes alleles among carriers of non-carriers of chemokine receptors CCR5del32, CCR2-64I and SDF- 1 3'A genes mutation was not significantly different. The obtained results on the spread of protective alleles in Ukrainian population would help to predict the epidemiological situation of HIV / AIDS in the future. Product Description popup.authors Акопян Гаяне Рубенівна Дмитрук Ірина Михайлівна Макух Галина Василівна Сосніна Катерина Олександрівна Терпиляк Ореста Ігорівна Тиркус Марта Ярославівна popup.nrat_date 2020-04-02 Close