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Information × Registration Number 0214U006954, 0113U006057 , R & D reports Title Identification of high-molecular methods of screening and early clinical studies of biologically active compounds - prototypes of drugs to combat methabolic, cardiovascular and cancer popup.stage_title Head Boyko Aleksandr.N, Registration Date 15-04-2014 Organization Taras Shevchenko Kiev university popup.description2 A pharmacophore model of medical targets GPR-119, GPR-40 nf SIRT6, developed a search algorithm likopodibnyh means to structural and biological characteristics. Done in silico screening activators GPR-119, GPR-40, SIRT6 p from the collection of 2 mln.spoluk of which is selected for further studies 22 000 compounds from an existing database and further synthesized over 3000 compounds. A preliminary biological screening collections of compounds with a total of over 11 000 thousand. We found 7 compounds with biological activity at the level of the best world analogues perspektyvnyhz Product Description popup.authors Бориско Петро Сергійович Зозуля Сергій Олексійович Платонов Максим Олегович Толмачов Андрій Олексійович Юрченко Володимир Володимирович popup.nrat_date 2020-04-02 Close