Registration Number
0214U006954,
0113U006057
, R & D reports
Title
Identification of high-molecular methods of screening and early clinical studies of biologically active compounds - prototypes of drugs to combat methabolic, cardiovascular and cancer
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Head
Boyko Aleksandr.N,
Registration Date
15-04-2014
Organization
Taras Shevchenko Kiev university
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A pharmacophore model of medical targets GPR-119, GPR-40 nf SIRT6, developed a search algorithm likopodibnyh means to structural and biological characteristics. Done in silico screening activators GPR-119, GPR-40, SIRT6 p from the collection of 2 mln.spoluk of which is selected for further studies 22 000 compounds from an existing database and further synthesized over 3000 compounds. A preliminary biological screening collections of compounds with a total of over 11 000 thousand. We found 7 compounds with biological activity at the level of the best world analogues perspektyvnyhz
Product Description
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Бориско Петро Сергійович
Зозуля Сергій Олексійович
Платонов Максим Олегович
Толмачов Андрій Олексійович
Юрченко Володимир Володимирович
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2020-04-02
