Search academic texts

Information × Registration Number 0214U007000, 0113U005350 , R & D reports Title 3-Phosphorylated 1,2-dihydro-3H-1,4-benzodiazepine-2-ones: synthesis, conversion and pharmacological properties popup.stage_title Head Andronati S.A., Registration Date 27-03-2014 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 A series of phosphorylated 1,4-benzodiazepine-2-ones has been synthesized. By condensation 5-aryl-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepine-2-ones obtained with the corresponding diphenylchlorophosphine 3-diphenyphosphineoxyde-1,2-dihydro-3H-1,4-benzodiazepine-2-ones, which occurs during heating Arbuzov rearrangement. 1-Propyl derivative standard rearrangement occurs to form the C-P bond in the third position of the 1,4-benzodiazepine geterotskla whereas Case 1-unsubstituted derivatives unusually it passes , to form products 3 - or 5-phosphorylated derivatives of 1,4-benzodiazepine-2-one, in which case there is migration of the double bond from the position 4-5 to the position 3-4. Product Description popup.authors В. І. Павловский Е. Вороненко Е. Халимова Н. Ильюшко Т. Кабанова Т. Юрпалова Т.Л. Карасева Я. Кривенко popup.nrat_date 2020-04-02 Close