Search academic texts

Information × Registration Number 0214U007001, 0113U005350 , R & D reports Title 3-Phosphorylated 1,2-dihydro-3H-1,4-benzodiazepine-2-ones: synthesis, conversion and pharmacological properties popup.stage_title Head Andronati S.A., Registration Date 27-03-2014 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 A number of new 3-or 5-phosphorylated 1,4-benzodiazepine-2-ones. The structure of obtained compounds is confirmed by IR spectroscopy, 1H and 31P -NMR and mass spectrometry. For 4 compounds identified by X-ray molecular structure analysis. All the compounds exhibit neurotrophic and analgesic activity. The analgesic activity ( ED50 ) of the synthesized compounds are in the range from 0.9 to 0.1 mg / kg , while the reference compound diclofenac sodium 10,00 ± 1,80 mg / kg. Affinity for TSBDR CNS : ІС50 = from 112 to 2000 nm. For INEOS 60 g synthesized starting with 7- bromo-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepine-2-one. Product Description popup.authors В. Павловский Е. Вороненко Е. Халимова Н. Ильюшко Т. Кабанова Т. Юрпалова Т.Л. Карасева Я. Кривенко popup.nrat_date 2020-04-02 Close