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Registration Number

0214U007125, 0113U007554 , R & D reports

Title

Ammonium-selective composites as a basis of highly-sensitive test-systems for detection of markers of kidney disfunction - creatinine, urea and arginine.

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Head

Zinchenko Olena Anatoliivna,

Registration Date

18-04-2014

Organization

Institute of Molecular Biology and Genetics

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A laboratory prototype of the electrode highly sensitive to ammonium ions is proposed. It is based on the PANi/Nafion/copper nanocomposite and was fabricated using the layer-by-layer electrodeposition. The optimum technology of modification of carbon electrodes with copper nanoparticles and polianiline membrane is elaborated. Control experiments were performed to determine the sensitivity of PANi/Nafion/copper nanocomposite to creatinine and urea. The electrochemical and analytical properties of the designed PANi/Nafion/copper nanocomposite on the printed carbon electrode surface were determined: the lowest value of measurable concentration of ammonium ions (LOD), linear range of measuring the ammonium chloride concentration (linearity range), an influence of electrolytes in the buffer solution on the chemosensor performance, pH-dependence of the nanocomposite work. All the measurements were carried out in the phosphate buffer, pH 7.4, the electrolyte composition and pH of which maximumally simulate the structure and environment of blood serum.5481

Product Description

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Жибак М.Т.
Зінченко О.А.
Чан Д.Х.

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2020-04-02