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Information × Registration Number 0214U008030, 0111U006259 , R & D reports Title New heterocyclic compounds - effective sources of biologically-active substances, fluorescent probes, modifiers of supramolecular objects popup.stage_title Head Volovenko Yu. M., Registration Date 03-06-2014 Organization National Taras Shevchenko University of Kiev popup.description2 Report : 101 p., 110 рiсt., 6 tаbl., 1 addition, 53 references. Research object: nitrogen-, oxygen- and sulfurcomprising geterosystems. Work aim: The development and improvement of preparative methodes and methodics of synthesis of novel geterocyclic compounds for making of novel bioregulators of widespread-spectrum of range, novel photosensitive and fluorescent materials. Research methodes: Methodes of synthesis of model organic substances, geterocyclic substances; NМR-, IR-, UV-, fluorescent spectroscopy; mass- and chromatomass-spectroscopy; methodes of synthesis under high pressure and inert atmosphere; XR- and elemental analysis. The methodes of synthesis of 2-amino-3-hetaryl-4,5-dihydrotiophene-4-ones and -pirrolyn-4-ones were studied by means of acylation of hetarylacetonitriles by acylchlorides of cyclic N-trifluoroacetyl-a-amino acides and S-acetyl a-mercapto acides. The methods of alkylation, acylation and nucleophylic addition to activated triple bond of 2-hetaryliden-3-оxo-4-sulphanylbutane nitriles were fond. The reactions of isoindole derivatives in isoindolenine tautomeric form with cyclic dieniphyles were studied. The Mikhaele bis-adductes were obtained in the reaction of isoindoles with maleinimides. The reaction of 2-alkyl-1-aminoisoindoles with maleinimides in arranged medium without catalyst was realized. The methodes of synthesis of new spirocyclic system 9-оxo-1,4-diazaspiro[5.5]undecane were developed and a possibility of this diamine selectiv modification was disclosed. The methodes of synthesis of new 3-hetarylsubstituted flavonoids of isocumarine structure, 2-(2-(het)aryl-2-oxoethyl)benzamides, new pyridinic acides and aminoacides were developed. The systematic investigation of Mannikh bases on the base of 7-hydoxyneoflavones synthesis, the transformation of 7-hydoxyneoflavone enaminoketones, the reactions of 3-aryl/aryloxy/hetaryl-chromones with hydrazine hydrate and hydroxylamine were realized. The methodes of selective acylation of rezacetophenone were developed, the photonics of oxycoumarine dyes and biological activity of 3-(hydroxyphenyl)- and 3-(dihydroxyphenyl)isocoumarines were studied. An effective methodes of synthesis of 1-amino-alcylphosphonates of aminophosphonic and aminophosphinic acides of thiazole were developed. The results of SRW were applied: into subjects of Chemical department of Taras Shevchenko National University of Kyiv. Product Description popup.authors Єгорова Т.В. Бійцева А.В. Бойко О.М. Воловенко Ю.М. Горбуленко Н.В. Кіндер Т.Д. Кисіль А.І. Коваленко Н.В. Левков І. В. Манойленко О.В. Москвіна В.С. Пласконь А.С. Потіха Л.М. Ткачук Т.М. Туров В.О. Цапко М.Д. Чекотило О.О. Шилін С.В. Шишкіна О.О. Шокол Т.В. popup.nrat_date 2020-04-02 Close