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Information × Registration Number 0215U000320, 0112U003062 , R & D reports Title Creation of biologically active substances on the basis of N- and S- the replaced heterocycles containing nitrogen. popup.stage_title Head Omelyanchik Ludmila Alexandrivna, Registration Date 09-02-2015 Organization Zaporozhye National University popup.description2 The object of research - is molecular design of biologically active compounds, which is based on derivatives of endogenous nitrogen heterocycles; development of new transformation methodic; studying of complexing properties of the S- and N-substituted six-membered nitrogen heterocycles; studying of interconnection "structure - physicochemical properties - toxicity, biological effects". The purpose of work is to create new, effective and low toxic bioregulators of antioxidant, anti-ischemic, neurotropic, cerebroprotective, growth promoting, anti-microbial etc... actions among endogenous N- and S-substituted six-membered nitrogen-containing heterocycles. Another goal is identifying of the probable mechanisms of action of the most active compounds. Developed effective compound N- and S-substituted six-membered nitrogen-containing heterocycles for their further use in medicine, veterinary and agriculture. The dependence - "structure - physical and chemical properties - toxicity, biological effect" have been established. It was found, that the proposed mechanism of cerebroprotective action of 2 (pyridine-4-ylthio) succinic acid is realized by antihypoxic and antioxidant properties, namely the ability to inhibit overproduction of active oxygen forms. The preparative methods for the synthesis of 50 new compounds, which include N- and S-substituted six-membered nitrogen-containing heterocycles, have been developed. For the first time, the antiradical activity of some synthesized compounds as "traps" superoxide anion, was investigated . The most effective derivatives of 1,2,3,4-tetrahydro-pyridine. First established the presence of the stimulating effect of S-substituted pyridine thioacids on a synthesis pigment, in a pigment forming bacteria(the genera Pseudomonas and Serratia marcescens) and bacteriostatic activity of some S-substituted acridine for B. subtilis and S. aureus. The antidepressive activity of new compounds from S-hetaryl substituted thioacids, with the help of Porsolt test, was studied, and on the basis of its data their ability to reduce the period of immobility was proved. The search for compounds with growth-promoting action among S-hetaryl substituted thioacids and their derivatives was proved as beneficial and patented method of germinating cucumber seeds in a solution of the dihydrochloride of S- (pyridin-4-yl) -L-cysteine. Laboratory regulation on the method of synthesis, physico-chemical and biological properties of the "connection - leader" - the disodium salt of 2- (pyridin-4-ylthio) succinic acid was developed. It is determined that this substance on antidepressant activity is close to the standard of comparison ("Velaksin"), the antioxidant effect is greater than the reference drugs - "thiotriazoline", "Emoksipin" and "N-acetyl-L- cysteine, "and for a neuroprotective effect exceeds" Mexidol ", which is a prototype of this substance. Scope : in medicine, veterinary medicine and agriculture. Product Description popup.authors Бражко Олександр Анатолійович Генчева Вікторія Іванівна Завгородній Михайло Петрович Корнет Марина Миколаївна Омельянчик Людмила Олександрівна Панасенко Тамара Володимирівна Петруша Юлія Юріївна Рильський Олександр Федорович Синяєва Ніна Петрівна popup.nrat_date 2020-04-02 Close