Search academic texts

Registration Number

0215U000515, 0113U000132 , R & D reports

Title

Association between MGP and VDR gene polymorphism with the development of ischemic stroke

Head

Ataman Alexandr Vasilievich,

Registration Date

27-02-2015

Organization

Sumy State University

Description

Association of polymorphic variants of genes MGP and VDR with atherothrombotic ischemic stroke (AIS) in Ukrainian population was first investigated. Found that the risk of AIS homozygotes for the minor allele of the A/A (G-7A polymorphism MGP) is 2.6 times higher than that of the primary carriers of allele - G/G and G/A. Found an association between AIS and polymorphic variants G-7A MGP gene in females. In women gomomozigot on minor allele A/A, the risk of stroke 6.6 times higher than that of the primary carriers of allele (G/A + G/G). The influence of single nucleotide polymorphisms of vitamin D receptor gene on the clinical characteristics of atherothrombotic ischemic stroke was studied. It was determined that in patients who have F/F, b/b, a/a, a/A, and T/T genotypes, statistically significant association between hypertension and IS development exists.

Product Description

popup.authors

Атаман Олександр Васильович
Бороденко Анастасія Олександрівна
Гарбузова Вікторія Юріївна
Дубовик Євген Іванович
Прасол Дарія Олександрівна
Шимко Карина Ашотівна