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Information × Registration Number 0215U001047, 0113U000261 , R & D reports Title Develop effective standard and individual chemotherapy regimens for treatment of pulmonary MDR tuberculosis popup.stage_title Head Feschenko Yuriy Ivanovich, Registration Date 14-01-2015 Organization SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine" popup.description2 Object: 777 patients with MDR TB. Aim: to determine the optimal chemotherapy regimens for patients with MDR TB depending on the number, amount of anti-TB drugs at the treatment regimen, the length of intensive and continuation phases of chemotherapy, which will increase the treatment efficasy and save public funds. Methods: clinical, radiological, laboratory, microbiological. In patients with MDR TB, XDR TB were determined in 25,2 % of cases, and resistance to fluoroquinolone (without XDR TB ) - in 10,4 % of cases, resistance to injectable anti-TB drugs - in 21,0 % of cases, mostly in previously treated cases of I-II lines anti-TB drugs. Risk factors for the development of XDR TB or fluoroquinolone resistance or resistance to injectable anti-TB drugs were established: using more than 2 years I-II lines anti-TB drugs, large and/or multiple cavities, the prevalence of infiltrative-focal changes, the application for the previous courses of fluoroquinolones and injectable anti-TB drugs more than 1 month , the presence of side effects to anti-TB drugs and excluding them due to this side effects, MDR contact. Individualized regimens for patients with XDR TB were developed: additional use of etionamid to 5 anti-TB drugs I-II lines, compared with regimes which used only 5 anti-TB drugs I-II lines without etionamid resulting to reseive sputum and culture conversion in 89,9% of patients, and to increase the treatment efficasy of 18,9 %, and was reduced the cost-effectiveness of chemotherapy regimen in patients with 402,4 to 322,6 UAH. Sphere of application - phthisiology Product Description popup.authors Бялик Йосип Борисович Веселовський Леонід Вікторович Гранкіна Наталія Вячеславівна Грицова Наталія Анатоліївна Давиденко Валентина Василівна Зайков Сергій Вікторович Кібізова Ніна Ігорівна Литвиненко Наталія Анатоліївна Пісковець Лариса Іванівна Погребна Марина Віталіївна Рева Олена Анатоліївна Сенько Юлія Олександрівна Черенько Світлана Олександрівна Чоботар Оксана Петрівна popup.nrat_date 2020-04-02 Close