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Information × Registration Number 0215U001048, 0113U000262 , R & D reports Title To study the mechanisms of development of metabolic disorders and work out the possibility of their correction in the experimental pulmonary edema popup.stage_title Head Korzhov Vitaliy, Доктор медичних наук Registration Date 14-01-2015 Organization SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine" popup.description2 Object - blood of white rats with experimental pulmonary edema (PE) injected sodium succinate with therapeutic purpose. Aim - to find violations of the state of glutathione-dependent detoxication system and oxidant-antioxidant system of blood and to justify the possibility of pharmacological therapy in experimental PE. Methods - experimental, biochemical, histological, statistics. The application of sodium succinate for therapeutic purpose in middle therapeutic dose in experimental PE enhances sorption capacity of red blood cells, reduction of the nuclear fraction of middle mass molecules in red blood cells and plasma, reduce the concentration of lipid peroxidation products, and glutathione -dependent activation of enzyme. The degree of corrective action of the drug, its antioxidant properties depend on the applied dose of adrenaline - at larger dose of adrenaline to simulate PE the maximal effect on investigated biochemical systems is revealed. It was established that the effect of sodium succinate on the nature and severity of demonstration of histological signs which directly characterize the hemodynamic PE, to reactive changes in lung tissue has a different degree of presentation at different doses of adrenaline and associated to some extent with the time of observation. Sphere of application - pulmonology Product Description popup.authors Жадан Вікторія Миколаївна Касьян Наталія Анатоліївна Коржов Віталій Іванович Лоза Тетяна Василівна Любченко Вікторія Михайлівна Олексинська Ольга Олександрівна popup.nrat_date 2020-04-02 Close