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Total number
Full text
Number of local repositories
Full text
0215U001048,
0113U000262
,
To study the mechanisms of development of metabolic disorders and work out the possibility of their correction in the experimental pulmonary edema
Korzhov Vitaliy, Доктор медичних наук
14-01-2015
SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine"
Object - blood of white rats with experimental pulmonary edema (PE) injected sodium succinate with therapeutic purpose. Aim - to find violations of the state of glutathione-dependent detoxication system and oxidant-antioxidant system of blood and to justify the possibility of pharmacological therapy in experimental PE. Methods - experimental, biochemical, histological, statistics. The application of sodium succinate for therapeutic purpose in middle therapeutic dose in experimental PE enhances sorption capacity of red blood cells, reduction of the nuclear fraction of middle mass molecules in red blood cells and plasma, reduce the concentration of lipid peroxidation products, and glutathione -dependent activation of enzyme. The degree of corrective action of the drug, its antioxidant properties depend on the applied dose of adrenaline - at larger dose of adrenaline to simulate PE the maximal effect on investigated biochemical systems is revealed. It was established that the effect of sodium succinate on the nature and severity of demonstration of histological signs which directly characterize the hemodynamic PE, to reactive changes in lung tissue has a different degree of presentation at different doses of adrenaline and associated to some extent with the time of observation. Sphere of application - pulmonology
Жадан Вікторія Миколаївна
Касьян Наталія Анатоліївна
Коржов Віталій Іванович
Лоза Тетяна Василівна
Любченко Вікторія Михайлівна
Олексинська Ольга Олександрівна
2020-04-02
Updated: 2025-12-14
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