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Registration Number

0215U001056, 0113U000270 , R & D reports

Title

To improve the diagnostic of tuberculosis infection in children

Head

Belogortseva Olga Ivanovna,

Registration Date

14-01-2015

Organization

SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine"

Description

Object: 76 children with newly diagnosed tuberculosis (NDTB), 57 children with residual changes after tuberculosis (RCTB). Aim: to improve the quality of TB care for children through the development and implementation of technology intradermal tests for the diagnosis of different manifestations of tuberculosis infection in children. Methods: clinical, laboratory and statistical. It was found that 94.7 % of children with tuberculosis had the positive intradermal test with recombinant allergen tuberculosis (RAT) and this confirms the activity of tuberculosis. RCTB were diagnosed in 52.6 % of children by the way of routine tuberculin testing which confirms its effectiveness as a screening method for early diagnosis of local forms of tuberculosis in children. The negative or questionable test results with 45.7 % APR to allow to exclude an active tuberculosis process in children with RCTB. Dynamics of test with ART results can be the criterion of tuberculosis treatment efficiency. In all children with local forms of NDTB the specific activation of immunity with deficiency of phagocytic immunity has been found. It has been proved that children 10-16 years old with local TB, had a secondary immune deficiency by cellular and humoral immunity. Sphere of application phthisiology, pediatrics

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Андрєєва Олена Германівна
Білогорцева Ольга Іванівна
Доценко Ярослава Ігорівна
Копосова Ірина Вікторівна
Победьонна Галина Павлівна
Рагузіна Тетяна Борисівна
Сіваченко Оксана Єфремівна
Садловська Марія Анатоліївна
Фірсова Алла Сергіївна
Шатунова Вікторія Анатоліївна
Шехтер Ірина Євгеніївна