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Information × Registration Number 0215U001151, 0110U006130 , R & D reports Title Nanoconjugates of novel antitumor agents based on the specific ligands of quadruplex DNA - inhibitors of telomerase popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 29-01-2015 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 A series of new ligands of quadruplex DNA based on acridine and cyanine derivatives were synthesized. Among them telomerase inhibitors active at 10-20 uM concentration were found. Nanoconjugates of inhibitors, porphyrin MP3 and cyanine LO-8, with dextran, PMLA and polyethylene glycol were obtained. The study of some active inhibitors and their conjugates in tumor cell cultures revealed antitumor activity at low micromolar concentrations. Low toxicity of the agents was established. It was shown that nanoconjugates efficiently penetrate the cell. Interaction of TMP3 and TC-30 ligands with Tel22 quadruplex was modeled by PM7 method. Product Description popup.authors Ільченко Микола Миколайович Авдєєв Станіслав Сергійович Арешков Павло Олександрович Дубей Лариса Василівна Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close