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Information × Registration Number 0215U002319, 0112U001027 , R & D reports Title Study of the clinic-pathogenesis mechanisms of the undifferential dysplasia of the connection tissue on the remodelation of elastic-tissue structures of the organism of the human popup.stage_title Head Nikolenko Yevgenii Yakovlevich, Registration Date 27-04-2015 Organization Kharkov National University named after V.N. Karazin popup.description2 The object of study - the exchange of connective tissue, remodeling of biological structures. Purpose - study of connective tissue metabolism in patients with chronic obstructive pulmonary disease (COPD) professional genesis and the study of processes of adjustment frame heart in these patients. Materials and methods. Were examined 750 working adults and 249 persons with a diagnosis of occupational diseases in enterprises engineering. The diagnosis of COPD according to the criteria established by order of the Ministry of Health of Ukraine №128 19.03.2007. Isolated core group of COPD I, II and III severity and control group. The patients were in remission without concomitant respiratory diseases. The main group consisted of 715 persons (515 men and 200 women) aged 20 to 67 years. Of the total number of persons who are sick, 474 people (66.3%), increased work performed (three) categories of severity; 259 people were taken ill (36.2%) worked in an environment where dust was a major production factor. Dust in combination with noise, vibration and high temperature air was present at the workplace of 153 people. For laboratory diagnostic methods for the study were randomly selected 143 patients. Complex examination included medical history (including experience in hazardous conditions and characteristics of jobs), general clinical, health, clinical and epidemiological and statistical methods. Research of connective tissue - the level of free hydroxyproline and hydroxyproline related peptide (FH and HRP) glukosoaminoglikany (GAG) and their fractions, atypical antibodies to collagen (AK) - IgG, IgM in serum. Revealed that the level of FH and HRP varies depending on the severity of COPD. Level FH virtually unchanged in the first degree COPD and significantly increased in the second degree (p <0,05) and does not increase in the third degree. HRP level continues to rise in the third degree COPD (p <0.05). Dependencies overall GAG severity of COPD were found. The difference was between a main group of COPD patients and control group - patients GAG level was higher. More informative was the dynamics of GAG fractions depending on the degree of COPD. Maximum high levels of antibodies to the AK was in the second degree COPD, and in patients with third degree to AK antibody levels declined. Established in the early stages of the disease there are structural changes of the right ventricle (RV) and symptoms of pulmonary hypertension. RV free wall thickness was significantly different from the control group and already at stage COPD. Central pulmonary artery pressure in patients with COPD during the first degree 6%, while the third stage 43.3% higher than a flashy among the control group. The functionality of the pulmonary artery in terms Acct / Rvet reduced by 27% the second stage compared to the first stage COPD, and in patients with III st. COPD, this value are 42.5% less than in the first degree COPD. In working on industrial production, which are harmful factors (such as dust) develops violation of the state of connective tissue (collagen, GAG), followed by the emergence of COPD severity is related to the term work in hazardous conditions. Product Description popup.authors В.Савченко К.Вовк Н.Пилипенко О.Захаров О.Сокруто О.Шевченко popup.nrat_date 2020-04-02 Close