Registration Number
0215U003045,
0111U010159
, R & D reports
Title
To carry out experimental study of radioprotective properties of modified thiol compounds.
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Head
Uzlenkova N.E.,
Registration Date
16-01-2015
Organization
Grigor'ev Institut for Medical Radiology
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Object - radioprotective properties of the synthesized compounds S-heteryl modified thiols. Purpose - to evaluate radioprotective properties of the synthesized compounds created on the basis of S-heteryl modified thiols (S-heteryl modified cysteine). Methods and equipment - radiobiological, hematological, biochemical, spectrophotometric, morphological, statistical. Equipment: X-ray unit RUM-17, universal dosimeter UNІDOS, automated biochemical analyzer Express Plus, microscopes Zeiss "Axіolab", Leica DM 6000B, object-micrometer, analytical balances. Theoretical and practical results - The assessment of radioprotective activity of several novel chemical compounds, namely S-heteryl modified thiols, was carried out on the model of acute radiation injury and resulted into identifying of the radioprotective activity of hydrochloride S-(6-ethoxy-2-methylquinoline-4-il)-cysteamine with the dose reduction factor of 1.82. Theoretical results include the establishing of the mechanisms of hematoprotective activity of hydrochloride S-(6-ethoxy-2-methylquinoline-4-il)-cysteamine via the reduction of radiation-induced apoptosis in bone marrow and rescuing all hematopoietic lineages, as it occurred for erythrocytes, leukocytes and platelets score in blood. Maximum efficiency was determined for the minimum absolute lethal X-ray dose. Other radioprotective effects observed in rodents with acute radiation syndrome included the abrogation of early radiation-related death, normalization of serum enzyme system and the preservation of morphological structure of internal organs. Novelty - The radioprotective activity of hydrochloride S-(6-ethoxy-2-methylquinoline-4-il)-cysteamine was established for the first time. Efficiency - established radioprotective properties of the substance will allow expanding the range of radioprotective agents in the future. Scope (area) of use - radiobiology, radiation protection.
Product Description
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Артамонова Н.О.
Громакова І.А.
Гуз Ю.М.
Дзюбенко Н.О.
Дригваль А.А.
Куров О.М.
Леонова І.О.
Магда І.Ю.
Маматкулова Т.М.
Масленнікова О.Л.
Ненюкова О.В.
Пасюга В.М.
Скоробогатова Н.Г.
Узлєнкова Н.Є.
Цховребова А.І.
Шелковая Л.П.
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2020-04-02
