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Registration Number

0215U003046, 0113U000049 , R & D reports

Title

The comparative analysis of cytogenetic effects in cancer patients undergoing gamma- 60Co radiotherapy on "ROCUS" and megavolt photon therapy on linear accelerator

Head

Maznyk N.A.,

Registration Date

16-01-2015

Organization

Grigor'ev Institut for Medical Radiology

Description

Object of study - cytogenetic effects in cultured lymphocytes of cancer patients with different tumor localizations under the megavolt photon exposure during radiation therapy on linear accelerator. The aim - to assess the cytogenetic effects in lymphocytes of cancer patients following radiation treatment, depending on the energy of radiation dose and tumor localization, in order to improve biodosimetry in radiation therapy. Research methods and techniques - cytogenetic analysis of human blood cultured lymphocytes, statistical methods of data processing, light microscopes Zeiss Axioskop, Micros MC300X, Olympus BX43. Theoretical and practical results - the overspontaneous yield of chromosomal damage before treatment was present in all patients groups, regardless of tumor localization. The different character of chromosomal and chromatid type aberrations accumulation in groups of patients with various tumor localizations was found. The monotonous increase of the level of chromosome type aberrations from the beginning to the end of treatment in all groups of patients was demonstrated, however, its' rate was different depending on tumor localization. The frequency of chromatid type aberrations significantly increased only in the group with lung cancer during megavolt photon therapy. These data are of importance for correct assessment of the impact of megavolt photon therapy at the chromosomal level. Novelty - within one study the quantitative yield and quality range of cytogenetic damage in lymphocytes of patients with uterine cancer, lung cancer and head and neck cancer before and during megavolt photon therapy on linear accelerator. The effectiveness of implementation - The opportunity to provide timely biological dosimetry for radiotherapy cases and for other exposure scenarios. Area of application - radiobiology, radiation therapy.

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Ірха О.Е.
Артамонова Н.О.
Білозор Н.В.
Вінніков В.А.
Дашкова С.А.
Дригваль А.А.
Забобоніна Л.В.
Колпакова Л.К.
Кругова І.М.
Міхановський О.А.
Мазник Н.О.
Пшенічна Н.Д.
Пшишевська Л. А.
Святенко Н.І.
Сипко Т.С.
Старенький В.П.
Шустов І.Б.