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Registration Number

0215U003048, 0114U000057 , R & D reports

Title

To determine the prognostic role of angiogenesis synthesis as possible markers in evaluation of efficacy of chemoradiation therapy for non-small-cell lung cancer.

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Head

Starenky V.P., Mitryaeva N.A.,

Registration Date

16-01-2015

Organization

Grigor'ev Institut for Medical Radiology

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Research objective. To define prognostic criteria of treatment control of non-small-cell lung cancer on the basis of the study of angiogenesis regulators expression as markers of efficacy of the chemoradiation therapy. Research methods. Clinical instrumental, immunoenzymometric, electron microscopy, dosimetric, statistical; linear accelerator Clinac 600C, immunoenzymometric analyzer. Theoretical and practical results. Content of angiogenesis regulator VEGF and oncomarker CYFRA 21-1 in the blood serum of patients with non-small-cell lung cancer was estimated as well as relation between VEGF level and clinical morphological characteristics of the disease in dynamics of conformal radiotherapy in gradual chemoradiation therapy was established. Higher efficacy of conformal radiation therapy of non-small-cell lung cancer with involvement of primary focus in radiation process in comparison with involvement of primary focus and lymph nodes in radiation volume was shown. Statistically significant increase of VEGF content in patients with non-small-cell lung cancer in comparison with control group was proved. Novelty. Dependence of expression of VEGF on stage of disease, degree of malignancy and lymph nodes involvement as well as applicability of VEGF and CYFRA 21-1 for monitoring of efficacy of radiation therapy was shown for the first time. Implementation effectiveness. Applicability of VEGF and CYFRA 21-1 as markers of efficacy of chemoradiation therapy of non-small-cell lung cancer has been proved. Area of application - radiation therapy, oncology.

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Білозор Н.В.
Бакай Т.С.
Басилайшвілі С.Ю.
Волошина Н.М.
Гребіник Л.В.
Зміївський В.В.
Канцедал О.М.
Карвасарська В.В.
Лукашова О.П.
Мітряєва Н.А.
Насонова А.М.
Павліченко Ю.В.
Панов О.В.
Потапова Т.І.
Пшишевська Л.А.
Синиченко О.В.
Спузяк Р.М.
Старенький В.П.
Тарасова О.М.
Тесленко І.М.
Ткаченко А.А.
Федоренко К.С.

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2020-04-02