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Registration Number

0215U003059, 0112U006840 , R & D reports

Title

Translation aparatus in cytosol: their role in mitochondrial translation and antioxidant homeostasis

Head

Negrutskii B.S,

Registration Date

19-01-2015

Organization

Institute of Molecular Biology and Genetics of NASU

Description

Oncogene PTI- 1 was identified in prostate cancer cell culture and human invasive prostate adenocarcinoma , but not in healthy tissue .During the third phase, we obtained important findings to suggest an alternative not previously known mechanism PTI -1 tumorigenicity, which is that the PTI-1 mRNA can be matrix for relaxin-like peptide (uPTI-1) synthesis. Since relaxin brought to oncogenesis, uPTI-1 peptide can interact with the corresponding specific to the relaxin receptor. It is not excluded that this specific use, aberrant mechanism, and thus, it can contribute to the development of prostate cancer mediated by relaxin.

Product Description

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Висловух А.А
Власенко Д.О
Капустян Л.М
Новосильна О.В
Порубльова Л.В
Тросюк Т.В.
Шалак В.Ф.