Registration Number
0215U003244,
0112U000023
, R & D reports
Title
Improve treatment of patients with malignant tumors of the chest
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Head
Ganul Valentin Leonidovich,
Registration Date
22-01-2015
Organization
Ukrainian Research Institute of Oncology and Radiology
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The object of study - patients with malignant tumors of the chest cavity. Purpose - to increase the effectiveness of the treatment of patients with malignant tumors of the chest cavity through the improvement and optimization of methods and techniques of treatment. Methods of research - clinical, laboratory, radiographic, statistics. Equipment: ROCUS, infusion pump, peristaltic pump. During the research work improved: neoadjuvant chemotherapy method for the treatment of patients with no-small cell lung cancer IIA-IIIA stages (complete and partial tumor regression in 85.0 % of patients, longer disease-free period from 14.6 to 18.7 months) and methods of postoperative administration autovaccines on the basis of dendritic cells in the treatment of patients with small cell lung cancer IIB - IIIA stages (improvement in median survival from 23.5 to 37.1 months); individualized methods of treatment of patients with malignant tumors of the mediastinum on the basis of the main characteristics of the process (histological structure, localization, tumor incidence). The most effective approach to treatment are complex and combined, in which the radical removal of the tumor contributes neoadjuvant chemotherapy and / or radiation therapy, and the use of individualized treatment techniques can save performance in a larger number of patients, which leads to an increase in the receipt of funds from income tax from the wages (Every year about 600 million grn). A method for the treatment of patients with malignant tumors of the chest wall - neoadjuvant regional chemotherapy is fully justified and highly effective, and radical removal of the tumor with resection of the chest wall in combination with the subsequent reconstruction of the defect and the creation of a rigid framework can achieve good functional and cosmetic results, as well as significantly improve the quality of life of these patients.The efficacy of surgical and complex treatment of patients with metastatic malignant tumors in the lungs. The choice of treatment of patients with lung metastases depends on the nature of the primary tumor, radicalism before the treatment, the volume of the lung tumor. Improved method intrapleural chemoypertermic perfusion in combination with systemic chemotherapy in the treatment of patients with malignant pleural mesothelioma can achieve sustainable pleurodesis, which significantly improves the quality of life of patients. Improvements: a technique of neoadjuvant radiotherapy in combination with selective polychemotherapy (increased frequency of response compared to conventional methods of treatment from 50 to 70 %) and selective catheterization technique using digital subtraction angiography in the treatment of patients with esophageal cancer; technique combined treatment of patients with locally advanced gastric cancer involving esophagus using neoadjuvant chemotherapy (increase annual survival rate from 72 % to 78.5 %). It was found that stenting is the most effective method of removing and aesthetic of dysphagia in patients with unresectable or complications of esophageal cancer than gastrostomy (increase in median life from 3 to 4.7 months). Formation of bypasses in the treatment of patients with unresectable or complications gastric cancer involving esophagus increases the median life from 3.3 to 4.9 months, and their imposition reduces the overall cost of treatment in 2-2.5 times (every year about 5.5 million grn). The results are of considerable economic, scientific and social importance. Region of application of the developed methods of treatment can be a wide range of medical facilities with cancer.
Product Description
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Борисюк Богдан Онуфрійович
Бороров Леонід Васильович
Ганул Андрій Валентинович
Захаричев Валерій Димитрович
Кіркілевський Станіслав Ігорович
Кондрацький Юрій Миколайович
Крахмальов Павло Сергійович
Совенко Володимир Михайлович
Супруненко Олександр Анатолійович
Шевченко Анатолій Іванович
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2020-04-02
