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Information × Registration Number 0215U003245, 0112U000017 , R & D reports Title To develop the methods of the treatment for patients with malignant tumors of the abdomen popup.stage_title Head Shchepotin Igor Borysovich, Registration Date 22-01-2015 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The object of study - patients with cancer of the stomach, pancreas, rectum and colon, neorhanni retroperitoneal tumor. The purpose of research - to increase the effectiveness of treatment of patients with malignant tumors of the abdominal cavity through the development of new methods of surgery, chemotherapy and radiotherapy. Methods: clinical, laboratory, instrumental, radiation, statistics. Results of the combined treatment of patients with gastric cancer with neoadjuvant chemotherapy using PELF regiment. Personalization treatment of patients by according for molecular profiling of tumors provided an opportunity to increase the number of partial regression 2.5-3 times, lower the total cost of treatment. Developed and applied multimodal program Fast track surgery for patients with pancreatic cancer using modified techniques reconstructive stage pancreatic-duodenal resection makes it possible to reduce the number of postoperative complications by 25%, to accelerate the rehabilitation period. The technique combined surgery with removal of malignant tumors of the retroperitoneum, with resection and / or extirpation surrounding organs or structures and total removal of retroperitoneal fat, which reduced the incidence of local recurrence in 2 times, from 45.4% to 22.7% (p = 0.02 ), the median disease-free survival rates increase to 90 months compared to 47 months. patients with standard surgery (p = 0.022). Studied in terms of randomized trial results of combined treatment locally advanced rectal cancer using radiotherapy ( 2 Gy x 15) and two chemotherapy regimens. Tumor regression was more significant in patients with oxaliplatin and capecitabine use, respectively 60% and 32%, a two-year overall survival rates in the study group were on 8 % higher, than at control (p<0.05). The algorithm synchronous (combined) and landmark liver resection in patients with metastatic rectal cancer was studied. Established that combined resection improves quality of life, reduce the length of surgery and patients stay in the hospital, to achieve the best results overall 3-year survival compared with two-stage resection, 61.9% and 40.0% (p < 0.001) respectively. Application FTS program in patients with colon cancer reduced the level of postoperative complications in 2.3 times. Indicators for the overall two-year survival of patients who had postoperative complications class II-IV for Clavien - Dindo, the survival was lower than in patients without complications: (58,3 ± 11,9)% vs (72,9 ± 14,6)% respectively (p = 0.924). The obtained results have significant national economic, scientific and social significance. Results of research introduced the National Cancer Institute, Zhytomyr, Mykolaiv, Poltava, Chernihiv, Khmelnytsky Regional Oncology Center. Forward assumptions about the object of study - improvement indications, operative technique in patients with tumors of the abdominal cavity. Product Description popup.authors Бурлака Антон Анатолієвич Вовк Марія Олександрівна Жуков Юрій Олександрович Колеснік Олена Олександрівна Лукашенко Андрій Володимирович Махмудов Дмитро Ельдарович Розумій Дмитро Олександрович Шалімов Сергій Олександрович popup.nrat_date 2020-04-02 Close