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Registration Number

0215U003386, 0110U005957 , R & D reports

Title

Development and analysis of biomodulating effect of nanocomplex of magnetic nanoparticles with nanoparticles of cyclodextrine aggregates; neurotoxicity risk assessment of its application in nanoneurotechnology.

Head

Borisova Tatiana Alrxamdrovna,

Registration Date

28-01-2015

Organization

A.V.Palladin Institute of Biochemistry of National Academy of Sciences

Description

Functionally active brain nerve terminal labelled with -Fe2O3 nanoparticles coated by D-mannose, and Fe3O4 nanoparticles coated with polymers were obtained, and the methodical approach manipulating nerve terminals by magnetic field using these nanoparticles was developed, neurotoxicity of these nanoparticles was assessed. The binding of nanoparticles to nerve terminals suggests that these nanoparticles can be used in nanoneurotechnology in the treatment by local hyperthermia. - The specific effects of protein and inorganic components of natural complex ferritin, which contains natural magnetic nanoparticles, to modulate the transport of neurotransmitters in brain nerve terminals were shown. - Using ssynthesized nanocomplex cyclodextrin / magnetic nanoparticle, a new strategic approach and methodology for extraction followed by removal of cholesterol outside of brain nerve terminals was developed. It was shown that in pathological states, i.e. ischemic / hypoxic brain injury, accompanied by an increase in transporter-mediated glutamate release from nerve terminals, nanoparticles of cyclodextrin aggregates have a neuroprotective effect.

Product Description

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Касаткіна Л.О.
Крисанова Н.В.
Назарова А.Г.
Позднякова Н.Г.
Сівко Р.В.
Трикаш І.О.