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Registration Number

0215U004036, 0112U002127 , R & D reports

Title

To learn the molecular-genetic links of pathogeny of unmaturing of pregnancy

Head

Vorobjeva I.I., Skrepchenko N.J.,

Registration Date

29-01-2015

Organization

State organization "Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine"

Description

Scientific research paper report. 86p., 12 tab., 45 sourc. The research object were women with noncarrying of pregnancy in past history. The goal of the research was to: decrease the number of perinatal loses for women with noncarrying of pregnancy by developing a complex of treatment and prophylactic measures during pregravidal and gravidal periods based on studying molecular and genetic predictors for noncarrying of different classes. The scientific novelty of the paper is based on the fact that for the first time in our country there was conducted a complex research of polymorphism of genes of different classes, which stipulated the creation of a noncarrying development concept based on discovered genetic defects in immunohormonal regulation, detoxification, blood coagulation, folat exchange and endothelial function systems, which allowed to develop new approaches to diagnostics, prophylactics and treatment of this category of women. The paper is based on quite a significant amount of material. Over the course of three years we studied 153 women with increased risk factors for miscarriage on accident-control design according to current instructions and recommendations of Ministry of Health of Ukraine. Institute of Molecular Biology and Genetics also participated in this research. All the numerical data was processed using modern mathematical methods. The study allowed us to educe national features of genetic polymorphism, that define the mechanisms of forming of habitual noncarrying of pregnancy and the influence of different factors in this process. The complex of curative and prophylactic measures we developed allowed to prevent obstetric complications and loses among women with Leiden mutation, with homozygotic genes of folat exchange, nitrogen oxide, ACE, glycoprotein, interleukin and their compounds. The presence of pathological polymorphism in at least 5 genes of different classes or 2-3 genes of thrombophilia increase the chances of miscarriage by 32-54 times. Acquired results should be used for developing new approaches to diagnostics, prognostication and treatment of miscarriage.

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Живецька-Денисова А.А.
Могілевська С.І.
Писарева С.П.
Рудакова Н.В
Ткаченко В.Б.
Толкач С.М.
Черненко Т.С.
Шамаєва О.В.