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Information × Registration Number 0215U004512, 0111U006259 , R & D reports Title New heterocyclic compounds - effective sources of biologically-active substances, fluorescent probes, modifiers of supramolecular objects popup.stage_title Head Khilya V.P., Registration Date 28-05-2015 Organization National Taras Shevchenko University of Kiev popup.description2 Report : 101 p., 110 рiсt., 6 tаbl., 1 addition, 53 references. Research object: nitrogen-, oxygen- and sulfurcomprising geterosystems. Work aim: The development and improvement of preparative methodes and methodics of synthesis of novel geterocyclic compounds for making of novel bioregulators of widespread-spectrum of range, novel photosensitive and fluorescent materials. Research methodes: Methodes of synthesis of model organic substances, geterocyclic substances; NМR-, IR-, UV-, fluorescent spectroscopy; mass- and chromatomass-spectroscopy; methodes of synthesis under high pressure and inert atmosphere; XR- and elemental analysis. The synthetic methodes of 1,4-benzothiazepines, 2Н-1,5-benzoxathiepines, 5H-4,1-benzoxathiepines and methods of their functionalization through oxidation , saturation, Vilsmeier, with DMFADMA,bromine, with electrophiles and nucleophiles, Strecker, Corey - Chaykovsky, Horner - Wadsworth - Emmons reactions, and rearrangement conditions were developed. A new approach to the synthesis of 1,2,8-triazaspiro[4.5]decane derivatives was developed. The structure of the most promising compounds for further synthesis - pyrrolidin-2,5-dione derivatives was determined according to in silico screening. The synthetic conditions of 3-hetaryl substituted pyrrolidin-2,5-diones, Michael bis-adducts in the reactions of 2-aminopyridines and 2-aminothiazole with maleimides, 3-(9H-fluoren-9-yl)pyrrolidin-2,5-dione, 3-fluoren-pyrrolidin-2,5-dione were found and optimized. A new approach to the synthesis of several new synthetic amino acids, sulfamides and aminomethyl-3-arylisocoumarine derivatives, 3-hetarylisocoumarine derivatives was developed; the possibility of transformation into isoquinolines and condensed systems of 6-(isocoumarin-3-yl)-4-alkyl-umbelliferone of them; new methodes of synthesis of several graveolone analogues, pyranoneoflavones, 2Н-chromen-2-one was developed and the use of 2-imino-3-hetarylcoumarine, 3-hetarylchromone heteroanalogs as fluorescent probes was showed and suggested. The functionalization of coumarines with alkaloids remains and isoflavone glycoside residues was conducted. The biological activity of 3-azolylchromone, synthetic chromane, imidazo(thiazolo)pyrazolopyrimidine derivatives was investigated. A simple synthesis procedure of pyrazolo[3,4-d]-4,5-dihydropyrimidines and their condensed derivatives was developed. The results of SRW were applied: into subjects of Chemical department of Taras Shevchenko National University of Kyiv. Product Description popup.authors Єгорова Т.В. Бійцева А.В. Бойко О.М. Горбуленко Н.В. Кіндер Т.Д. Кисіль А.І. Левков І. В. Любчук Т.В. Манойленко О.В. Матвіюк Т.В. Москвіна В.С. Пласконь А.С. Потіха Л.М. Тарасюк Т.М. Туров В.О. Хиля В.П. Цапко М.Д. Шилін С.В. Шишкіна О.О. Шокол Т.В. popup.nrat_date 2020-04-02 Close