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Information × Registration Number 0215U004533, 0111U000518 , R & D reports Title Fundamentals of technology a new putative antitumour cytokine EMAP II and its mutant forms with increased antiangiogenic effect popup.stage_title Head Kornelyuk Alexander Ivanovich, Registration Date 04-06-2015 Organization Institute of Molecular Biology and Genetics popup.description2 Interaction cytokine EMAP II with hydroxypropyl-beta-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin was investigated by fluorescence spectroscopy. A nanocomposite systems with these substances were created. To study the impact of EMAP II beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and nanocomposite EMAP II complexes with beta-cyclodextrin and EMAP II complexes with hydroxypropyl-beta-cyclodextrin used Bohdena test. Pieces of tumor weight at 1 mg sit alongside the kidney capsule of mice CBA and the substance injected under the skin. Introduction mice beta-cyclodextrin caused no significant changes in histological structure ksenohraftiv prostate cancer compared with the control group, which received animals solvent. The use of hydroxypropyl-beta-cyclodextrin resulted in growth edema and the appearance of epithelial cells with hyperchromic nuclei. In ksenohraftah prostate cancer from animals injected EMAP II increased infiltration of leukocytes and epithelial cells appeared with hyperchromic nuclei. With the introduction of animals EMAP II complex with beta-cyclodextrin structure epithelium ksenohraftiv not appreciably different from the application of such other EMAP II, when administered EMAP II complex with hydroxypropyl-beta-cyclodextrin appreciated infiltration of leukocytes, increased the number of cells with hyperchromic nuclei and chromatin parietal location in the nuclei. Thus, the use of function complex EMAP II with hydroxypropyl-beta-cyclodextrin was slightly more effective than EMAP II with beta-cyclodextrin or EMAP II. Product Description popup.authors Бабенко Л.А. Козлов Олександр Вадимович Малина А.М. Резніков Олександр Григорович Чайковська Людмила В'ячеславівна popup.nrat_date 2020-04-02 Close