Registration Number
0215U004762,
0110U006663
, R & D reports
Title
Role and mechanisms of lipid transport failure in atherosclerosis pathogenesis
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Head
Savitsky Ivan Vladimirovich, Доктор медичних наук
Registration Date
01-12-2015
Organization
Odessa State Medical Universitu
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It was firstly demonstrated that heparinemia level determines the lipoproteinlipase activity changes as well as the peculiarities of lipid-transport system restructurization. The lipid-transport system disturbances in pathological conditions with hyperheparinemia symptoms were shown firstly to have both antiatherogenic character and pro-atherogenic predisposition. Lipoproteinlipase activity decrease was found to be a 'trigger point' of this system destruction on the tissue level as the result of lipoproteinlipase activity decrease due to hypoheparinemia in case of mast cells depletion. A new concept of atherosclerosis pathogenesis is adopted which allow to develop preventive and rehabilitative measures to improve the clinical status of patients ischemic cardiac disease and hypertension. The new algorithm of lipid-transport system functional activity identification was proved to reduce patients' duration in the hospital and extend their life.
Product Description
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Бабій Валентина Павлівна
Гончарова Лілія Володимирівна
Котюжинська Світлана Георгіївна
Савицький Іван Володимирович
Свірський Олександр Олексанндрович
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2020-04-02
