Registration Number
0215U004773,
0113U001634
, R & D reports
Title
Development of the criteria of effectiveness and safety for pharmacotherapy of the patients with tuberculosis and hepatitis of different origin on the base of pharmacogenetic investigations
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Head
Kresyun Valentin Iosiphovich,
Registration Date
01-12-2015
Organization
Odesa National Medical University
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In presented work it is found that detection of GSTР1 gene polymorphism in patients could be a predictor of development and treatment efficiency of chronic virus hepatitis C. At the end of in-patient treatment the processes of dissolving of tuberculosis infiltrate and absence of pulmonary destruction were observed in 100% of "slow metabolizers", according to CYP2C9 genotype, in 91,0 and 82,8 % "intermediate" and "rapid metabolizers" correspondently"; in "slow acetylators" according to NAT2 genotype, tuberculosis destruction of lungs aborted in 1,3 times faster than in "rapid acetylators". At the moment of discharge from hospital in "slow acetylators" the alanine aminotransferase and aspartate aminotransferase activity were on 23,2 and 26,4% higher than in "rapid acetylators". In patients with "rapid acetylators" genotype at the ending of in-patient treatment the multidrug resistant tuberculosis appeared in 3,5 times more often than in patients with "slow acetylators" genotype.
Product Description
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Амосова Альона Володимирівна
Антоненко Катерина Олексіївна
Антоненко Петро Борисович
Бажора Юрій Іванович
Годован Владлена Володимирівна
Ермуракі Павло Петровчи
Кресюн Валентин Йосипович
Остапчук Катерина Володимирівна
Тимчишин Олег Львович
Чеснокова Марина Михайлівна
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2020-04-02
