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Information × Registration Number 0215U006062, 0111U010494 , R & D reports Title To establish the peculiarity of reproductive disease were occasioned by neonatal or local hypertermia and the possibility of pharmacological correction by thiazolinyamide camphoric acid popup.stage_title Head Karpenko Nina Oleksiivna, Registration Date 30-01-2015 Organization State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine" popup.description2 Object of study: disorders of the reproductive function biological active substances. Purpose - establishment of disorders of reproductive function of male individuals that have arisen as a result of various etiological factors and correction capabilities using tiazolinilamidu camphor acid. Methods - physiological, morphological, cytological, biochemical, HRP, pharmaceutical technological, organic synthesis, analytical chemistry. It was established that different etiology options of reproductive disorders (neonatal induced dysprohramna hypofertility and primary hypogonadism as a result of local hyperthermia of the scrotum in adult male rats) are characterized by a specific combination of existing disorders, which reduces the fertility of males. Sexually mature young males are resistant to the action of local hyperthermia medium degree, in adult males practically stops spermatogenesis and develops infertility and asexuality. In modeling of neonatal dysprogramm reproductopathies created male model of hypofertility a significant decrease in fertility Phi integrated while maintaining almost normal spermatogenesis and sexual behavior. Revealed changes do not explain the deterioration fertilization ability of sperm and significant growth of embryonic loss in these males fertilized females, indicating the nature of idiopathic hypofertility males. The reaction DL-, D- and L-camphor anhydride with 2 aminotiazolin among 2-propanol obtained camphor tiazolinilamid racemic acid (TCC) and its enantiomers. The peculiarities of molecular and spatial structure of the compound is a 3 (4,5dyhidrotiazol-2-yl) amide cis-1,2,2 trymethylcyklopentan 1,3-dicarboxylic acid, characterized in the solid state form associates involving the amide carbonyl group one molecule with the carboxyl group of the second, and the solutions - envelope-like preferred conformation of cyklopentan cycle of lowered 2.2 dymethyl fragment. It was proved that the left rotating enantiomer of the compound (L-TCC) more effectively than its racemic form or reference product speman corrects induced neonatal disorders of the male reproductive function and leads to the restoration of fertility in adult animals. For the treatment effects of local hyperthermia effectiveness racemic and L- forms of TCC to restore the fertility of males less than spemana. D-TCC was effective in restoring sexual activity of males. The complex of pharmaco-technological and analytical studies of oral and soft drugs from TCC. Formulated features of the process of production, investigated the stability, the conditions and shelf life of prepared sections technological and analytical documentation on medical forms TCC. Scope: endocrinology, andrology, pharmacy. Product Description popup.authors Бойко Марина Володимирівна Вакула Володимир Миколайович Величко Наталія Федорівна Карпенко Ніна Олексіївна Карпова Тетяна Олексіївна Коренєва Євгенія Михайлівна Кравченко Світлана Вікторівна Кустова Світлана Петрівна Ларьяновська Юлія Борисівна Нікішина Людмила Евгенівна Пащенко Юлія Геннадівна Петровська Вікторія Вячеславівна Почерняєва Софія Сергіївна Свидло Ірина Миколаївна Селюкова Наталія Юріївна Смоленко Наталія Павлівна Сомова Олена Віталіївна Черняєва Олена Іванівна Чистякова Еліна Евгенівна Яременко Федір Георгійович popup.nrat_date 2020-04-02 Close