Search academic texts

Registration Number

0215U006085, 0112U001250 , R & D reports

Title

To explore the mechanisms of damage of cell membranes in patients with limb girdle dystrophy muscular dystrophy.

Head

Tantsura L.M.,

Registration Date

02-02-2015

Organization

State Institution " Institute neurology, psychiatry and narcology AMS of Ukraine"

Description

The objects of the study are mononuclear cells of peripheral blood that come from patients, diagnosed with limb girdle dystrophy muscular dystrophy. The aim of the work is to determine the mechanisms of cell membranes reaction on the mechanical stress in the conditions of genetically determined defect of structural proteins of muscles. The results of research work are as follows: using the original, developed in the course of scientific work, research model of response to mechanical stress of peripheral blood mononuclear cells, which come from patients, diagnosed with limb-girdle muscular dystrophy, there were established the certain regularities and specific features of these reactions at different limb-girdle muscular dystrophies. We have found violation of transport functions of membranes due to mechanical stress, their specific characteristics at different limb-girdle muscular dystrophies and a significant role in ensuring the stability of mitochondrial membranes to mechanical damage and the possibility of cells to repair.

Product Description

popup.authors

Соколік В.
Степаненко Н.
Танцура Л.
Трембовецька О.
Шатілло А.